Epidermolysis+bullosa+(EB)


 * //__Epidermolysis Bullosa: __//**

 **__What is Epidermolysis Bullosa? __** Epidermolysis Bullosa, also known as EB, is an inherited genetic skin disease that causes the formations of blisters on any skin surface. The blisters can occur either through inflicted/ induced injuries, spontaneous break outs, heat, friction from rubbing and scratching. This disorder does not affect any specific race or ethnicity. There are four types of Epidermolysis Bullosa: Dystrophic epidermolysis bullosa , Epidermolysis bullosa simplex , Hemidesmosomal epidermolysis bullosa , Junctional epidermolysis bullosa. Scientist and doctors have found that each of these types of EB also contain sub types with in them. It is most commonly found in infants, but symptoms may occur later in one’s life making the disorder to be fatal.     **__<span style="color: #333333; font-family: 'Times New Roman',serif; font-size: 12pt;">What are the symptoms? __**
 * <span style="font-family: 'Times New Roman',serif; font-size: 12pt;">Blistering of the skin (severity depends on widespread and type).
 * <span style="font-family: 'Times New Roman',serif; font-size: 12pt;">Hair loss.
 * <span style="font-family: 'Times New Roman',serif; font-size: 12pt;">Deformity of nails and toenails.
 * <span style="font-family: 'Times New Roman',serif; font-size: 12pt;">Internal blistering (throat, stomach, intestines, oesophagus).
 * <span style="font-family: 'Times New Roman',serif; font-size: 12pt;">Excessive sweating.
 * <span style="font-family: 'Times New Roman',serif; font-size: 12pt;">Trouble swallowing.
 * <span style="font-family: 'Times New Roman',serif; font-size: 12pt;">Dental deformity (tooth decay).
 * <span style="font-family: 'Times New Roman',serif; font-size: 12pt;">Acne (milia).
 * <span style="font-family: 'Times New Roman',serif; font-size: 12pt;">Breathing problem**s.**

<span style="font-family: 'Times New Roman',serif;"> **__<span style="font-family: 'Times New Roman',serif; font-size: 12pt;">How does Epidermolysis Bullosa occur? __** <span style="font-family: 'Times New Roman',serif; font-size: 12pt;">As said earlier, EB is inherited. Researchers have found around ten genes associated with Epidermolysis Bollusa. They also <span style="font-family: 'Times New Roman',serif; font-size: 12pt;"> added that it is possible that a random gene mutation could have occurred during the formation of an egg and a sperm. Other researchers have claimed to have found the most common gene responsible for Epidermolysis Bullosa: COL7A1; otherwise known as collagen, type VII, alpha I. Collagen is a protein that strengthens skin and bones. <span style="font-family: 'Times New Roman',serif;">

**__<span style="font-family: 'Times New Roman',serif; font-size: 12pt;">What are the limitations of Epidermolysis Bullosa? __** <span style="font-family: 'Times New Roman',serif; font-size: 12pt;">There are many limitations that come along with this disorder. EB prevents those who suffer from it to have a normal enjoyable life; no physical contact, no sunbathing, no sports. Those who are diagnosed with EB are under a very limited leisure list.

**__<span style="font-family: 'Times New Roman',serif; font-size: 12pt;">One World Factor: Social __** <span style="font-family: 'Times New Roman',serif; font-size: 12pt;">As mentioned on a previous section, the disorder does not allow the patient suffering from EB to have a so called normal social life style. His or her routine is altered from those who have no diagnosis. The patients are forbidden to damage their skin any further by adding friction, absorbing heat, or having a simple show of affection such as a hug. Not only are they isolated physically but also emotionally. Being different may cause severe emotional stress and pain. Being diagnosed can affect a human being both physically and emotionally.

**__<span style="font-family: 'Times New Roman',serif; font-size: 12pt;">One World Factor: Economic __** <span style="font-family: 'Times New Roman',serif; font-size: 12pt;">In order to prevent Epidermolysis Bullosa, prior tests must be taken. Meaning that a genetic specialist would have to examine all your genes, this could cost one thousands and thousands of dollars. Once one has been diagnosed with Epidermolysis Bullosa, one must take care of themselves very carefully. The skin being affected the most, should be treated well; this ranges from simple skin care such as daily injections and lotions to surgery (skin grafting) to even physical therapy. Unfortunately there is no proper cure for EB, the most one can do is prevent excess outburst of blisters. **__<span style="font-family: 'Times New Roman',serif; font-size: 12pt;">Bibliography: __** <span style="background-color: white; font-family: 'Times New Roman',serif; font-size: 12pt;">Board, A.D.A.M. Editorial. "Causes, Incidence, and Risk Factors." // Epidermolysis Bullosa //. U.S. National Library of Medicine, 18 Nov. 0000. Web. 10 Mar. 2012. <http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0002428/>. <span style="background-color: white; font-family: 'Times New Roman',serif; font-size: 12pt;">"COL7A1." // - Collagen, Type VII, Alpha 1 //. <span style="background-color: white; font-family: 'Times New Roman',serif; font-size: 12pt;">Web. 9 Mar. 2012. <http://ghr.nlm.nih.gov/gene/COL7A1>. <span style="background-color: white; font-family: 'Times New Roman',serif; font-size: 12pt;">"Donate." // About EB //. Debra. Web. 10 Mar. 2012. <http://www.debra.org/abouteb>. <span style="background-color: white; font-family: 'Times New Roman',serif; font-size: 12pt;">"Epidermolysis Bullosa." // The Free Dictionary //. <span style="background-color: white; font-family: 'Times New Roman',serif; font-size: 12pt;">Farlex. Web. 07 Mar. 2012. <http://www.thefreedictionary.com/Epidermolysis Bullosa>. <span style="background-color: white; font-family: 'Times New Roman',serif; font-size: 12pt;">"Epidermolysis Bullosa." // Q&A //. July 2009. Web. 12 Mar. 2012. <http://www.niams.nih.gov/Health_Info/Epidermolysis_Bullosa/default.asp>. <span style="background-color: white; font-family: 'Times New Roman',serif; font-size: 12pt;">"Health Guide." // Epidermolysis Bullosa //. NY Times. <span style="background-color: white; font-family: 'Times New Roman',serif; font-size: 12pt;">Web. 08 Mar. 2012. <http://health.nytimes.com/health/guides/disease/epidermolysis-bullosa/overview.html>. <span style="background-color: white; font-family: 'Times New Roman',serif; font-size: 12pt;">Macnair, Trisha. "Epidermolysis Bullosa." // BBC News //. BBC. Web. 7 Mar. 2012. <http://www.bbc.co.uk/health/physical_health/conditions/epidermolysis1.shtml>. <span style="background-color: white; font-family: 'Times New Roman',serif; font-size: 12pt;">Marinkovich, Peter. "Epidermolysis Bullosa." // Mescape //. <span style="background-color: white; font-family: 'Times New Roman',serif; font-size: 12pt;">Web. 09 Mar. 2012. <http://emedicine.medscape.com/article/1062939-overview>. <span style="background-color: white; font-family: 'Times New Roman',serif; font-size: 12pt;">Staff, Mayo Clinic. "Definition." // Mayo Clinic //. Mayo Foundation for Medical Education and Research, 27 Sept. 2011. <span style="background-color: white; font-family: 'Times New Roman',serif; font-size: 12pt;">Web. 9 Mar. 2012. <http://www.mayoclinic.com/health/epidermolysis-bullosa/DS01015>.